翻訳と辞書
Words near each other
・ Serosorting
・ Serostatus
・ Serostim
・ Serotine bat
・ Serotiny
・ Seroto
・ Serotonergic
・ Serotonergic cell groups
・ Serotonergic psychedelic
・ Serotonin
・ Serotonin (album)
・ Serotonin (disambiguation)
・ Serotonin acetyltransferase
・ Serotonin antagonist
・ Serotonin antagonist and reuptake inhibitor
Serotonin modulator and stimulator
・ Serotonin pathway
・ Serotonin receptor agonist
・ Serotonin releasing agent
・ Serotonin reuptake inhibitor
・ Serotonin syndrome
・ Serotonin transporter
・ Serotonin-dopamine releasing agent
・ Serotonin-dopamine reuptake inhibitor
・ Serotonin-norepinephrine releasing agent
・ Serotonin-norepinephrine-dopamine releasing agent
・ Serotonin–norepinephrine reuptake inhibitor
・ Serotonin–norepinephrine–dopamine reuptake inhibitor
・ Serotonylation
・ Serotta


Dictionary Lists
翻訳と辞書 辞書検索 [ 開発暫定版 ]
スポンサード リンク

Serotonin modulator and stimulator : ウィキペディア英語版
Serotonin modulator and stimulator
A serotonin modulator and stimulator (SMS), sometimes referred to more simply as a serotonin modulator, is a type of drug with a multimodal action specific to the serotonin neurotransmitter system. To be precise, SMSs simultaneously modulate one or more serotonin receptors and inhibit the reuptake of serotonin. The term was created to describe the mechanism of action of the serotonergic antidepressant vortioxetine (Brintellix/Trintellix), which acts as a serotonin reuptake inhibitor (SRI), partial agonist of the 5-HT1A receptor, and antagonist of the 5-HT3 and 5-HT7 receptors.〔(【引用サイトリンク】 author = American Pharmacists Association )〕〔(【引用サイトリンク】 author = Los Angeles Times )〕 However, it can also technically be applied to vilazodone (Viibryd), which is an antidepressant as well and acts as an SRI and 5-HT1A receptor partial agonist.
SMSs were developed because there are many different subtypes of serotonin receptors (at least 15 in total are currently known) and not all of these receptors appear to be involved in the antidepressant effects of SRIs. Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional role in the efficacy of SRIs in treating depression.〔 As such, a drug which combines the actions of, say, an SRI, 5-HT1A partial agonism, and 5-HT7 receptor antagonism, could, in theory, have the potential to prove more effective than pure SRIs. Alternatively, antagonism of 5-HT3 – a receptor that is involved in the regulation of nausea, vomiting, and the gastrointestinal tract – could counteract the undesirable increase in activation of this receptor mediated by SRIs, thereby potentially improving tolerability.
An alternative term is serotonin partial agonist/reuptake inhibitor (SPARI), which can be applied only to vilazodone.
==See also==

* Serotonin antagonist and reuptake inhibitor (SARI)
* Selective serotonin reuptake inhibitor (SSRI)
* Noradrenergic and specific serotonergic antidepressant (NaSSA)
* Tricyclic antidepressant (TCAs)

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Serotonin modulator and stimulator」の詳細全文を読む



スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース

Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.